Description
A short comedy about a secret division of the United States Postal Service.
Long Term Delivery (2018)
Genre: Comedy
Cast: Peter Smith, Mitch Giannunzio, James Foster, Jr., Marjorie Austrian, Harri Molese
Crew: Conor Murphy, Jake Honig, Jake Honig, Ariel Loh, Sandy Honig
Release: 2018-02-05
Budget: $3,994,998
Revenue: $96,921,195
Interior Designer: Effie Price
Library Technician: Loyal Kirlin
Biochemist: Harmon Bailey
Umpire and Referee: Mr. Camryn Stark
Umpire and Referee: Mr. Dimitri Hodkiewicz
Special Force: Justen Von
Telecommunications Facility Examiner: Prof. Tobin Bergnaum
Philosophy and Religion Teacher: Prof. Zoey Jacobi
Court Clerk: Alford Roberts
Janitorial Supervisor: Keely Mohr V
Manager Tactical Operations: Kayla Casper II
Protective Service Worker: Kayli Gorczany
Materials Scientist: Nicholaus Willms
Chemistry Teacher: Ms. Lilly Cruickshank
Manager Tactical Operations: Murray Feeney
Cast: Peter Smith, Mitch Giannunzio, James Foster, Jr., Marjorie Austrian, Harri Molese
Crew: Conor Murphy, Jake Honig, Jake Honig, Ariel Loh, Sandy Honig
Release: 2018-02-05
Budget: $3,994,998
Revenue: $96,921,195
Interior Designer: Effie Price
Library Technician: Loyal Kirlin
Biochemist: Harmon Bailey
Umpire and Referee: Mr. Camryn Stark
Umpire and Referee: Mr. Dimitri Hodkiewicz
Special Force: Justen Von
Telecommunications Facility Examiner: Prof. Tobin Bergnaum
Philosophy and Religion Teacher: Prof. Zoey Jacobi
Court Clerk: Alford Roberts
Janitorial Supervisor: Keely Mohr V
Manager Tactical Operations: Kayla Casper II
Protective Service Worker: Kayli Gorczany
Materials Scientist: Nicholaus Willms
Chemistry Teacher: Ms. Lilly Cruickshank
Manager Tactical Operations: Murray Feeney
Apr 7, 2014 ... ... Long-Term Care Crisis: Challenges in Financing and Delivery ... A n estimated 12 million Americans are currently in need of long-term ....
Long Term Delivery.
Thermogelling Polymer–Platinum(IV) Conjugates for Long-Term Delivery of Cisplatin.
May 15, 2018 ... A short comedy about a secret division of the United States Postal Service. 'Long Term Delivery' is this week's Staff Pick Premiere!.
Researchers have developed a drug capsule that remains in the stomach for up to two weeks after being swallowed, gradually releasing its drug payload over time. This type of drug delivery, developed at MIT and Brigham and Women’s Hospital, could eliminate lengthy drug regimens that require repeated doses, which would help to overcome one of the major obstacles to treating diseases such as malaria..
Long-term delivery of alendronate through an injectable tetra-PEG hydrogel to promote osteoporosis therapy - PubMed.
Injectable Polyplex Hydrogel for Localized and Long-Term Delivery of siRNA.
Pharmacotherapy for hypercalcemia, which is mainly caused by osteoporosis, is an effective method to regulate the in vivo calcium equilibrium. From this perspective, the development of a minimally invasive gelling system for the prolonged local delivery of bisphosphonates has practical significance ….
America’s Long-Term Care Crisis: Challenges in Financing and Delivery | Bipartisan Policy Center.
Long Term Delivery — Jake Honig.
Long-term delivery of protein therapeutics - PubMed.
Sep 24, 2014 ... On the other hand, encapsulation of protein in polymer matrix (injectable implants and particles) may provide long-term delivery of proteins..
May 17, 2018 ... Long Term Delivery ... Returning to Short of the Week for a second time, director Jake Honig follows-up his dramatic short Black Swell with this off- ....
In this study, we suggest a novel strategy of constituting an in situ-formed hydrogel composed of polymer–platinum(IV) conjugate to realize a long-term delivery of cisplatin. A unique conjugate was designed and synthesized by covalent linking of Pt(IV) complex to the hydrophobic end of two methoxyl poly(ethylene glycol)-b-poly(d,l-lactide) (mPEG–PLA) copolymer chains, resulting in the formation of Bi(mPEG–PLA)–Pt(IV). The conjugate could self-assemble into micelles in water, and its concentrated solution exhibited a thermoreversible sol–gel transition and formed a semisolid thermogel at body temperature. The incorporation of the cisplatin analogue Pt(IV) prodrug into the conjugate had a significant influence on its thermogelling properties and the conjugate thermogelation was attributed to the micellar aggregation. In vitro release experiments of Pt(IV)-conjugated thermogel showed that the platinum release lasted as long as two months. Furthermore, we demonstrated that the Pt(IV) prodrug was release.
Long Term Delivery by Jake Honig | Short Film.
Long-term delivery of protein therapeutics.
Here, we describe a concept for localized and long-term delivery of short interfering RNA (siRNA) using an injectable polyplex hydrogel possessing thermosensitivity and biodegradability properties. We prepared a low molecular weight polyethyleneimine–poly(organophosphazene) conjugate as a thermosensitive and cationic polymer that has a cleavable ester linkage. The conjugates formed about 100 nm sized polyplexes with siRNAs, and the polyplex solution turned into a polyplex hydrogel at body temperature via a hydrophobic interaction. We injected the polyplex hydrogel with siRNA of cyclin B1, an essential protein for controlling the cell cycle, into the tumor xenograft model. Polyplexes were slowly released from the polyplex hydrogel by dissolution and degradation, allowing an in vivo antitumor effect via cyclin B1 gene silencing for 4 weeks with only a single injection..
Long Term Delivery · A short comedy about a secret division of the United States Postal Service. · CAST · Agent 4505: Peter Smith Postmaster: Mitch Giannunzio.
Substantial advancements have been made in the field of extended protein delivery via various polymer-based formulations over last decade despite the unique delivery-related challenges posed by protein biologics. A number of injectable sustained-release formulations have reached market. However, the ….
New capsule achieves long-term drug delivery
Long Term Delivery.
Thermogelling Polymer–Platinum(IV) Conjugates for Long-Term Delivery of Cisplatin.
May 15, 2018 ... A short comedy about a secret division of the United States Postal Service. 'Long Term Delivery' is this week's Staff Pick Premiere!.
Researchers have developed a drug capsule that remains in the stomach for up to two weeks after being swallowed, gradually releasing its drug payload over time. This type of drug delivery, developed at MIT and Brigham and Women’s Hospital, could eliminate lengthy drug regimens that require repeated doses, which would help to overcome one of the major obstacles to treating diseases such as malaria..
Long-term delivery of alendronate through an injectable tetra-PEG hydrogel to promote osteoporosis therapy - PubMed.
Injectable Polyplex Hydrogel for Localized and Long-Term Delivery of siRNA.
Pharmacotherapy for hypercalcemia, which is mainly caused by osteoporosis, is an effective method to regulate the in vivo calcium equilibrium. From this perspective, the development of a minimally invasive gelling system for the prolonged local delivery of bisphosphonates has practical significance ….
America’s Long-Term Care Crisis: Challenges in Financing and Delivery | Bipartisan Policy Center.
Long Term Delivery — Jake Honig.
Long-term delivery of protein therapeutics - PubMed.
Sep 24, 2014 ... On the other hand, encapsulation of protein in polymer matrix (injectable implants and particles) may provide long-term delivery of proteins..
May 17, 2018 ... Long Term Delivery ... Returning to Short of the Week for a second time, director Jake Honig follows-up his dramatic short Black Swell with this off- ....
In this study, we suggest a novel strategy of constituting an in situ-formed hydrogel composed of polymer–platinum(IV) conjugate to realize a long-term delivery of cisplatin. A unique conjugate was designed and synthesized by covalent linking of Pt(IV) complex to the hydrophobic end of two methoxyl poly(ethylene glycol)-b-poly(d,l-lactide) (mPEG–PLA) copolymer chains, resulting in the formation of Bi(mPEG–PLA)–Pt(IV). The conjugate could self-assemble into micelles in water, and its concentrated solution exhibited a thermoreversible sol–gel transition and formed a semisolid thermogel at body temperature. The incorporation of the cisplatin analogue Pt(IV) prodrug into the conjugate had a significant influence on its thermogelling properties and the conjugate thermogelation was attributed to the micellar aggregation. In vitro release experiments of Pt(IV)-conjugated thermogel showed that the platinum release lasted as long as two months. Furthermore, we demonstrated that the Pt(IV) prodrug was release.
Long Term Delivery by Jake Honig | Short Film.
Long-term delivery of protein therapeutics.
Here, we describe a concept for localized and long-term delivery of short interfering RNA (siRNA) using an injectable polyplex hydrogel possessing thermosensitivity and biodegradability properties. We prepared a low molecular weight polyethyleneimine–poly(organophosphazene) conjugate as a thermosensitive and cationic polymer that has a cleavable ester linkage. The conjugates formed about 100 nm sized polyplexes with siRNAs, and the polyplex solution turned into a polyplex hydrogel at body temperature via a hydrophobic interaction. We injected the polyplex hydrogel with siRNA of cyclin B1, an essential protein for controlling the cell cycle, into the tumor xenograft model. Polyplexes were slowly released from the polyplex hydrogel by dissolution and degradation, allowing an in vivo antitumor effect via cyclin B1 gene silencing for 4 weeks with only a single injection..
Long Term Delivery · A short comedy about a secret division of the United States Postal Service. · CAST · Agent 4505: Peter Smith Postmaster: Mitch Giannunzio.
Substantial advancements have been made in the field of extended protein delivery via various polymer-based formulations over last decade despite the unique delivery-related challenges posed by protein biologics. A number of injectable sustained-release formulations have reached market. However, the ….
New capsule achieves long-term drug delivery
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